BioTox by Icare performs the in vivo test with mammalian erythrocyte micronuclei according to OECD 474 and in vitro mutagenesis and genotoxicity studies in accordance with Good Laboratory Practices (GLP).

Mutagenicity and genotoxicity according to ISO 10993-3 and ISO/TR 10993-33  

• Tests for reverse mutations in “Salmonella typhimurium his-” and “Escherichia coli” or Ames test (according to ISO 10993-3 and ISO/TR 10993-33 and OECD 471) 
• In vitro study of chromosomal aberrations in mammalian cells (human lymphocytes, CHO) (according to ISO 10993-3 and ISO/TR 10993-33 and OECD 473) 
• In vitro gene mutation tests in mammalian cells (L5178Y) (according to ISO 10993-3 and ISO/TR 10993-33 and OECD 490) 
• In vitro micronucleus test in mammalian cells (CHO) (according to ISO 10993-3 and ISO/TR 10993-33 and OECD 487) 
• Micronucleus test in rats (according to ISO 10993-3 and ISO/TR 10993-33 and OECD 474) 

Development of alternative tests to animal testing