Toxicology – Antiseptic, Disinfectant and Biocide
In vivo test Chemical products
Tolerance studies:
- Acute dermal irritation OECD 40
- Acute eye irritation OECD 405
Toxicity studies:
- Acute oral toxicity OECD 423/425/420
- Acute dermal toxicity OECD 402
- Repeated oral toxicity: OECD 407/408
Sensitization studies:
- Local lymph node assay (LLNA) OECD 442B
- Maximization test (Magnusson & Kligman) OECD 406
- Non-maximization test according to Buelher OECD 406
Mutagenicity and genotoxicity:
- Mammalian erythrocyte micronucleus test (rat) OECD 474
- Comet assay OECD 489
In vitro test Chemical products
Eye irritation:
- Reconstituted human corneal epithelium model OECD 492 (EpiOcular)
- Reconstituted human corneal epithelium model OECD 492B (SkinEthic)
- Acute eye irritation OECD 405
Skin irritation / Skin corrosion:
- Reconstructed human epidermis OECD 439
- Reconstructed human epidermis (corrosion) OECD 431
- In vitro membrane test OECD 435
Skin sensitization:
- In chemico skin sensitization (DPRA)* OECD 442C
- Keratinosens test method* OECD 442D
- Human cell line activation test (h-CLAT)* OECD 442E
Mutagenicity & genotoxicity:
- Gene mutation test on mammalian cells using the thymidine kinase gene OECD 490
- Reverse mutation test on bacteria (Ames) OECD 471
- Chromosome aberration test on human or rodent cells OECD 473
- In vitro micronucleus test on mammalian cells (CHO) OECD 487
** Tests carried out in partnership in accordance with Good Laboratory Practice.
For other tests, please consult us.
In vitro test Chemical products
Eye irritation:
- Reconstituted human corneal epithelium model OECD 492 (EpiOcular)
- Reconstituted human corneal epithelium model OECD 492B (SkinEthic)
- Acute eye irritation OECD 405
Skin irritation / Skin corrosion:
- Reconstructed human epidermis OECD 439
- Reconstructed human epidermis (corrosion) OECD 431
- In vitro membrane test OECD 435
Skin sensitization:
- In chemico skin sensitization (DPRA)* OECD 442C
Keratinosens* test method OECD 442D
Human cell line activation test (h-CLAT)* OECD 442E
Mutagenicity & genotoxicity:
- Gene mutation test on mammalian cells using the thymidine kinase gene OECD 490
- Reverse mutation test on bacteria (Ames) OECD 471
- Chromosome aberration test on human or rodent cells OECD 473
- In vitro micronucleus test on mammalian cells (CHO) OECD 487
** Tests carried out in partnership in accordance with Good Laboratory Practice.
For other tests, please contact us.
