Toxicology – Cosmetics industry

In vitro tests

Eye irritation:

  • Reconstituted human corneal epithelium model OECD 492 (EpiOcular)
    Reconstituted human corneal epithelium model OECD 492B (SkinEthic)

Skin irritation / Skin corrosion:

  • Reconstructed human epidermis OECD 439
    Reconstructed human epidermis OECD 431

Skin sensitization :

  • Skin sensitization in chemico (DPRA)* OECD 442C
  • Keratinosens test method OECD 442D
  • Human cell line activation test (h-CLAT) OECD 442E

Mutagenicity & genotoxicity:

  • Reverse mutation test in bacteria (Ames) OECD 471

(**) Tests carried out in partnership in accordance with Good Laboratory Practice.

In vitro test Chemical products

Eye irritation:

  • Reconstituted human corneal epithelium model OECD 492 (EpiOcular)
  • Reconstituted human corneal epithelium model OECD 492B (SkinEthic)
  • Acute eye irritation OECD 405

Skin irritation / Skin corrosion:

  • Reconstructed human epidermis OECD 439
  • Reconstructed human epidermis (corrosion) OECD 431
  • In vitro membrane test OECD 435

Skin sensitization:

  • In chemico skin sensitization (DPRA)* OECD 442C
  • Keratinosens test method* OECD 442D
  • Human cell line activation test (h-CLAT)* OECD 442E

Mutagenicity & genotoxicity:

  • Gene mutation test on mammalian cells using the thymidine kinase gene OECD 490
  • Reverse mutation test on bacteria (Ames) OECD 471
  • Chromosome aberration test on human or rodent cells OECD 473
  • In vitro micronucleus test on mammalian cells (CHO) OECD 487

** Tests carried out in partnership in accordance with Good Laboratory Practice.

For other tests, please contact us.

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